Grey’s Anatomy – Season 22 Cast, Schedule & Streaming Info

When Is the Next New Episode of Grey’s Anatomy?

The medical drama Grey’s Anatomy is currently airing its 22nd season on ABC. New episodes follow a consistent Thursday night schedule, though the network occasionally inserts breaks around major holidays.

Who Is in the Cast of Grey’s Anatomy Season 22?

The official cast page for season 22, maintained by Disney, lists a returning ensemble that includes Ellen Pompeo, Chandra Wilson, James Pickens Jr., Kevin McKidd, Caterina Scorsone, Camilla Luddington, Kim Raver, Chris Carmack, Anthony Hill, Jason George, Alexis Floyd, Harry Shum Jr., Adelaide Kane, Niko Terho, and Trevor Jackson. Several legacy characters, including George O’Malley and Mark Sloan, are not listed among the returning cast for this season.

Is George O’Malley Coming Back to Grey’s Anatomy?

No. The character George O’Malley, played by T.R. Knight, died at the end of season 5. He was hit by a bus while trying to save a woman, and his death was a major turning point for the early intern group. None of the current season 22 cast or episode listings reference a return for George O’Malley.

Did Eric Dane Leave Grey’s Anatomy?

Yes. Eric Dane, who played Mark Sloan (also known as McSteamy), left the show after season 9. His character died in the season 9 premiere. The official season 22 cast page does not list Eric Dane as part of the returning cast.

What Happened to Mark Sloan on Grey’s Anatomy?

Mark Sloan was a main character from season 2 through season 9. He died in the season 9 premiere after a plane crash and subsequent complications. His death, along with Lexie Grey’s, marked one of the most emotional arcs in the series.

What Is Grey’s Anatomy About?

Grey’s Anatomy is an American medical drama television series that premiered on March 27, 2005. It was created by Shonda Rhimes and is set at Grey Sloan Memorial Hospital in Seattle, Washington. The series follows the personal and professional lives of surgical interns, residents, and attendings, with a focus on relationships, ethical dilemmas, and high-stakes medical cases.

The show has produced 22 seasons and over 450 episodes as of 2025. Its theme song, Cosy in the Rocket by Psapp, has become instantly recognizable to fans. The series also launched two spin-offs: Private Practice (2007) and Station 19 (2018).

How Many Episodes Are in Grey’s Anatomy Season 1?

Season 1 of Grey’s Anatomy contains 9 episodes. This is notably shorter than later seasons, which often run 18-24 episodes. The first season introduced the core five interns: Meredith Grey, Cristina Yang, Izzie Stevens, Alex Karev, and George O’Malley, along with their attending surgeons Derek Shepherd and Miranda Bailey.

How Many Seasons of Grey’s Anatomy Are There?

As of 2025, there are 22 seasons. The show has been renewed annually by ABC since its debut. Season 22 began on October 9, 2025, and the network has confirmed an 18-episode order for this season.

How Can I Watch Grey’s Anatomy?

New episodes of Grey’s Anatomy season 22 air on ABC on Thursdays at 10 p.m. ET. They become available for streaming on Hulu the following day. In bundle markets, Hulu is also accessible through Disney+.

Older seasons (seasons 1 through 21) are available for streaming on Netflix in many regions. According to People, all 21 prior seasons are also available on Hulu and Netflix.

Is Grey’s Anatomy on Netflix?

Yes, but with a caveat. Grey’s Anatomy is on Netflix for many regions, but the most recent season (22) is not yet on Netflix in the United States. Older seasons are available, and the Netflix title page confirms the series is streaming there.

Where Is Grey’s Anatomy Streaming?

In addition to ABC and Hulu, Grey’s Anatomy is also available through Disney+ in certain bundle markets. The official ABC show page provides episode listings and streaming access.

Grey’s Anatomy: A Timeline of Key Events

• 2005: Series premiere. Season 1 introduces the core characters.
• 2006: George O’Malley’s death in season 5.
• 2009: Mark Sloan (Eric Dane) introduced; spin-off Private Practice launched.
• 2012: Mark Sloan death episode; Lexie Grey death.
• 2018: Station 19 spin-off premieres; crossover events begin.
• 2024-2025: Season 22 airs; original cast continues to reduce.

What Is Certain and What Remains Unclear

Why Grey’s Anatomy Has Lasted Two Decades

Grey’s Anatomy remains a cultural staple after two decades due to its blend of medical drama, character-driven storytelling, and willingness to rotate cast members. The show’s longevity has created a complex lore that new viewers can find intimidating, but it is structured in self-contained arcs. Recent seasons have tightened the cast focus, moving away from the ensemble internship model to a smaller core of senior surgeons.

Sources and Quotations

“Grey’s Anatomy is an American medical drama television series focusing on the personal and professional lives of surgical interns, residents, and attendings.”

— Wikipedia

“A drama centered on the personal and professional lives of five surgical interns and their supervisors.”

— IMDB

“The medical drama follows the personal and professional lives of the doctors at Seattle’s Grey Sloan Memorial Hospital.”

— ABC Official

Summary

Grey’s Anatomy season 22 is currently airing on ABC with new episodes on Thursdays at 10 p.m. ET. The cast includes a mix of long-running and newer characters, and legacy figures like George O’Malley and Mark Sloan are confirmed as deceased and not returning. For the latest updates on the Grey’s Anatomy season 22 cast, visit the official Disney page.

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